The GNAS<sup>R201C</sup> mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity.

Ostrander, Elizabeth L; Koh, Won Kyun; Mallaney, Cates; Kramer, Ashley C; Wilson, W Casey; Zhang, Bo; Challen, Grant A

The GNAS^R201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity.

Ostrander, Elizabeth L; Koh, Won Kyun; Mallaney, Cates; Kramer, Ashley C; Wilson, W Casey; Zhang, Bo; Challen, Grant A.

Afiliación

Ostrander EL; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Human and Statistical Genetics, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Koh WK; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Mallaney C; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Human and Statistical Genetics, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Kramer AC; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Wilson WC; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Zhang B; Center of Regenerative Medicine, Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Challen GA; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Developmental, Regenerative and Stem Cell Biology Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA. Electronic addres

Exp Hematol ; 57: 14-20, 2018 01.

Article en En | MEDLINE | ID: mdl-28939416

Asunto(s)

Cromograninas/genética; Subunidades alfa de la Proteína de Unión al GTP Gs/genética; Mutación con Ganancia de Función; Hematopoyesis/genética; Mutación Missense; Animales; Trasplante de Médula Ósea; Recuento de Células; Senescencia Celular; Cromograninas/fisiología; ADN Complementario/genética; Subunidades alfa de la Proteína de Unión al GTP Gs/fisiología; Redes Reguladoras de Genes; Genes Reporteros; Vectores Genéticos/genética; Hematopoyesis/fisiología; Células Madre Hematopoyéticas; Humanos; Lentivirus/genética; Linfopoyesis/genética; Ratones; Ratones Endogámicos C57BL; Transducción Genética; Quimera por Trasplante

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromograninas / Subunidades alfa de la Proteína de Unión al GTP Gs / Mutación Missense / Mutación con Ganancia de Función / Hematopoyesis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Exp Hematol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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