Stereoselective Synthesis of Functionalized Tetrahydro-1H-1,2-diazepines by N-Heterocyclic Carbene-Catalyzed [3 + 4] Annulation.
Org Lett
; 19(19): 5380-5383, 2017 10 06.
Article
en En
| MEDLINE
| ID: mdl-28949541
ABSTRACT
An efficient N-heterocyclic carbene (NHC)-catalyzed asymmetric [3 + 4] annulation reaction of N-Ts hydrazones with 2-bromoenals has been developed. A series of functionalized tetrahydro-1H-1,2-diazepines with two consecutive stereocenters was obtained using NHCs as the catalyst in good yields with excellent diastereo- and enantioselectivities.
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MEDLINE
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En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2017
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Article