Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release.
Pflugers Arch
; 470(1): 125-134, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-28951968
ABSTRACT
Chemical signaling strength during intercellular communication can be regulated by secretory cells through controlling the amount of signaling molecules that are released from a secretory vesicle during the exocytosis process. In addition, the chemical signal can also be influenced by the amount of neurotransmitters that is accumulated and stored inside the secretory vesicle compartment. Here, we present the development of analytical methodologies and cell model systems that have been applied in neuroscience research for gaining better insights into the biophysics and the molecular mechanisms, which are involved in the regulatory aspects of the exocytosis machinery affecting the output signal of chemical transmission at neuronal and neuroendocrine cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Gránulos Cromafines
/
Exocitosis
/
Técnicas Electroquímicas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Año:
2018
Tipo del documento:
Article
País de afiliación:
Suecia