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Mouse subthalamic nucleus neurons with local axon collaterals.
Gouty-Colomer, Laurie-Anne; Michel, François J; Baude, Agnès; Lopez-Pauchet, Catherine; Dufour, Amandine; Cossart, Rosa; Hammond, Constance.
Afiliación
  • Gouty-Colomer LA; INSERM U901, Marseille, France.
  • Michel FJ; Aix-Marseille University, UMR 901, Marseille, France.
  • Baude A; INMED, Marseille, France.
  • Lopez-Pauchet C; INSERM U901, Marseille, France.
  • Dufour A; Aix-Marseille University, UMR 901, Marseille, France.
  • Cossart R; INMED, Marseille, France.
  • Hammond C; INSERM U901, Marseille, France.
J Comp Neurol ; 526(2): 275-284, 2018 Feb 01.
Article en En | MEDLINE | ID: mdl-28971478
The neuronal population of the subthalamic nucleus (STN) has the ability to prolong incoming cortical excitation. This could result from intra-STN feedback excitation. The combination of inducible genetic fate mapping techniques with in vitro targeted patch-clamp recordings, allowed identifying a new type of STN neurons that possess a highly collateralized intrinsic axon. The time window of birth dates was found to be narrow (E10.5-E14.5) with very few STN neurons born at E10.5 or E14.5. The fate mapped E11.5-12.5 STN neuronal population included 20% of neurons with profuse axonal branching inside the nucleus and a dendritic arbor that differed from that of STN neurons without local axon collaterals. They had intrinsic electrophysiological properties and in particular, the ability to generate plateau potentials, similar to that of STN neurons without local axon collaterals and more generally to that of classically described STN neurons. This suggests that a subpopulation of STN neurons forms a local glutamatergic network, which together with plateau potentials, allow amplification of hyperdirect cortical inputs and synchronization of the STN neuronal population.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Axones / Núcleo Subtalámico / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Comp Neurol Año: 2018 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Axones / Núcleo Subtalámico / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Comp Neurol Año: 2018 Tipo del documento: Article País de afiliación: Francia