CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2.

Wang, Yingge; Chen, Lu; Tian, Zheng; Shen, Xueyi; Wang, Xiaohong; Wu, Honghai; Wang, Yayi; Zou, Jiayu; Liang, Jingyan

Wang, Yingge; Chen, Lu; Tian, Zheng; Shen, Xueyi; Wang, Xiaohong; Wu, Honghai; Wang, Yayi; Zou, Jiayu; Liang, Jingyan.

Afiliación

Wang Y; The Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Chen L; Research Center for Vascular Biology, College of Medicine, Yangzhou University, Yangzhou, China.
Tian Z; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Disease, Yangzhou University, Yangzhou, China.
Shen X; Research Center for Vascular Biology, College of Medicine, Yangzhou University, Yangzhou, China.
Wang X; The Department of Cardiology Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Wu H; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Disease, Yangzhou University, Yangzhou, China.
Wang Y; Research Center for Vascular Biology, College of Medicine, Yangzhou University, Yangzhou, China.
Zou J; Research Center for Vascular Biology, College of Medicine, Yangzhou University, Yangzhou, China.
Liang J; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Disease, Yangzhou University, Yangzhou, China.

Cell Biol Int ; 42(2): 187-193, 2018 Feb.

Article en En | MEDLINE | ID: mdl-28986953

Asunto(s)

Vasos Coronarios/citología; Células Endoteliales/inmunología; Endotelio Vascular/inmunología; Mediadores de Inflamación/metabolismo; Receptor Toll-Like 2/fisiología; Sistemas CRISPR-Cas; Células Cultivadas; Citocinas/biosíntesis; Células Endoteliales/efectos de los fármacos; Células Endoteliales/metabolismo; Endotelio Vascular/citología; Endotelio Vascular/metabolismo; Técnicas de Inactivación de Genes; Humanos; Molécula 1 de Adhesión Intercelular/metabolismo; Peptidoglicano/farmacología; Receptor Toll-Like 2/agonistas; Receptor Toll-Like 2/genética

Palabras clave

CRISPR-Cas9; TLR2; atherogenesis; coronary artery endothelial cell; inflammatory

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Endotelio Vascular / Mediadores de Inflamación / Vasos Coronarios / Células Endoteliales / Receptor Toll-Like 2 Límite: Humans Idioma: En Revista: Cell Biol Int Año: 2018 Tipo del documento: Article País de afiliación: China

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