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Engineering Cell Surface Function with DNA Origami.
Akbari, Ehsan; Mollica, Molly Y; Lucas, Christopher R; Bushman, Sarah M; Patton, Randy A; Shahhosseini, Melika; Song, Jonathan W; Castro, Carlos E.
Afiliación
  • Akbari E; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Mollica MY; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Lucas CR; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Bushman SM; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Patton RA; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Shahhosseini M; Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
  • Song JW; Department of Mechanical and Aerospace Engineering, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
  • Castro CE; Department of Mechanical and Aerospace Engineering, Biophysics Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.
Adv Mater ; 29(46)2017 Dec.
Article en En | MEDLINE | ID: mdl-29027713
ABSTRACT
A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos