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Flavonoid Composition and Biological Activities of Ethanol Extracts of Caryocar coriaceum Wittm., a Native Plant from Caatinga Biome.
Alves, Daniela Ribeiro; Maia de Morais, Selene; Tomiotto-Pellissier, Fernanda; Miranda-Sapla, Milena Menegazzo; Vasconcelos, Fábio Roger; da Silva, Isaac Neto Goes; Araujo de Sousa, Halisson; Assolini, João Paulo; Conchon-Costa, Ivete; Pavanelli, Wander Rogério; Freire, Francisco das Chagas Oliveira.
Afiliación
  • Alves DR; Veterinarian Sciences Post Graduation Program, Ceará State University, Av. Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.
  • Maia de Morais S; Veterinarian Sciences Post Graduation Program, Ceará State University, Av. Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.
  • Tomiotto-Pellissier F; Pathological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, PR 445, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
  • Miranda-Sapla MM; Pathological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, PR 445, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
  • Vasconcelos FR; Embrapa Agroindústria Tropical, Rua Dra. Sara Mesquita 2270, Planalto do Pici, 60511-110 Fortaleza, CE, Brazil.
  • da Silva ING; Veterinarian Sciences Post Graduation Program, Ceará State University, Av. Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.
  • Araujo de Sousa H; Chemical Course, Ceará State University, Av. Dr. Silas Munguba 1700, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.
  • Assolini JP; Pathological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, PR 445, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
  • Conchon-Costa I; Pathological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, PR 445, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
  • Pavanelli WR; Pathological Sciences Center, Londrina State University, Rodovia Celso Garcia Cid, PR 445, Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil.
  • Freire FDCO; Embrapa Agroindústria Tropical, Rua Dra. Sara Mesquita 2270, Planalto do Pici, 60511-110 Fortaleza, CE, Brazil.
Article en En | MEDLINE | ID: mdl-29081821
Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods. HPLC analysis of flavonoids revealed that isoquercitrin is the main flavonoid in both parts of the fruit, and peel extract showed the best antioxidant activity. In the inhibition of the acetylcholinesterase assay, both extracts demonstrate action comparable to physostigmine. The antimicrobial activity of extracts was evaluated against strains of Malassezia sp. and Microsporum canis, using the broth microdilution technique, in which the extracts showed similar MIC and MFC. The extracts present antileishmanial activity and low toxicity on murine macrophages and erythrocytes. Therefore, these results suggest a potential for the application of C. coriaceum fruit's ethanol extracts in the treatment against dermatophyte fungi and leishmaniasis, probably due to the presence of active flavonoids. Further in vivo studies are recommended aiming at the development of possible new pharmaceutical compounds.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2017 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2017 Tipo del documento: Article País de afiliación: Brasil