Ergostane steroids from the ethanol extract of Dysoxylum mollissimum.
J Asian Nat Prod Res
; 21(2): 103-108, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-29082753
ABSTRACT
Three new ergostane steroids, 7α-acetoxyl-ergosta-5,24(28)-diene-3ß,4ß,20S-triol (1), 7α-acetoxyl-ergosta-5,24(28)-diene-3ß,4ß-diol (2), and 7α-acetoxyl-ergosta-5,24(28)-3ß-ol (3) were isolated from the ethanol extract of stem bark of Dysoxylum mollissimum BI. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the isolated steroids were in vitro evaluated for their anti-inflammatory activity against COX-1 and COX-2. As a result, steroids 1-3 exhibited modest selective inhibition for COX-1 (>60%).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Esteroides
/
Extractos Vegetales
/
Meliaceae
/
Ergosterol
Límite:
Animals
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China