Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells.

Zimbone, Stefania; Monaco, Irene; Gianì, Fiorenza; Pandini, Giuseppe; Copani, Agata G; Giuffrida, Maria Laura; Rizzarelli, Enrico

Zimbone, Stefania; Monaco, Irene; Gianì, Fiorenza; Pandini, Giuseppe; Copani, Agata G; Giuffrida, Maria Laura; Rizzarelli, Enrico.

Afiliación

Zimbone S; Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
Monaco I; Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
Gianì F; Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy.
Pandini G; Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, via Palermo 636, 95122, Catania, Italy.
Copani AG; Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.
Giuffrida ML; Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Rizzarelli E; Institute of Biostructures and Bioimaging, National Council of Research (IBB-CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.

Aging Cell ; 17(1)2018 02.

Article en En | MEDLINE | ID: mdl-29094448

Asunto(s)

Péptidos beta-Amiloides/farmacología; Regulación de la Expresión Génica/efectos de los fármacos; Neuronas/efectos de los fármacos; Receptor IGF Tipo 1/efectos de los fármacos; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/metabolismo; Animales; Factor Neurotrófico Derivado del Encéfalo/efectos de los fármacos; Factor Neurotrófico Derivado del Encéfalo/genética; Humanos; Neuronas/metabolismo; Fragmentos de Péptidos/metabolismo; Ratas; Receptor IGF Tipo 1/genética; Receptores de Somatomedina/efectos de los fármacos; Transducción de Señal/efectos de los fármacos

Palabras clave

Alzheimer's disease; Aß monomers; BDNF; CREB; IGF1-R

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Péptidos beta-Amiloides / Receptor IGF Tipo 1 / Neuronas Límite: Animals / Humans Idioma: En Revista: Aging Cell Año: 2018 Tipo del documento: Article País de afiliación: Italia

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