The combinatorial effects of osmolytes and alcohols on the stability of pyrazinamidase: Methanol affects the enzyme stability through hydrophobic interactions and hydrogen bonds.

Pazhang, Mohammad; Mardi, Narges; Mehrnejad, Faramarz; Chaparzadeh, Nader

Pazhang, Mohammad; Mardi, Narges; Mehrnejad, Faramarz; Chaparzadeh, Nader.

Afiliación

Pazhang M; Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran. Electronic address: pazhang@azaruniv.ac.ir.
Mardi N; Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.
Mehrnejad F; Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran.
Chaparzadeh N; Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran.

Int J Biol Macromol ; 108: 1339-1347, 2018 Mar.

Article en En | MEDLINE | ID: mdl-29129628

Asunto(s)

Amidohidrolasas/química; Amidohidrolasas/metabolismo; Interacciones Hidrofóbicas e Hidrofílicas; Metanol/farmacología; Ósmosis/efectos de los fármacos; Estabilidad de Enzimas/efectos de los fármacos; Enlace de Hidrógeno; Simulación de Dinámica Molecular; Mycobacterium tuberculosis/enzimología; Conformación Proteica; Solventes/química

Palabras clave

Hydrogen bonds; Methanol; Pyrazinamidase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ósmosis / Metanol / Interacciones Hidrofóbicas e Hidrofílicas / Amidohidrolasas Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article

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