Single-unit activities during the transition to seizures in deep mesial structures.
Ann Neurol
; 82(6): 1022-1028, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29205475
ABSTRACT
Focal seizures are assumed to arise from a hypersynchronous activity affecting a circumscribed brain region. Using microelectrodes in seizure-generating deep mesial regions of 9 patients, we investigated the firing of hundreds of single neurons before, during, and after ictal electroencephalogram (EEG) discharges. Neuronal spiking activity at seizure initiation was highly heterogeneous and not hypersynchronous. Furthermore, groups of neurons showed significant changes in activity minutes before the seizure with no concomitant changes in the corresponding macroscopic EEG recordings. Altogether, our findings suggest that only limited subsets of neurons in epileptic depth regions initiate the seizure-onset and that ictogenic mechanisms operate in submillimeter-scale microdomains. Ann Neurol 2017 Ann Neurol 2017;821022-1028.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Lóbulo Temporal
/
Potenciales de Acción
/
Electroencefalografía
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Epilepsia Refractaria
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Ann Neurol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia