[Mucous membrane pemphigoid]. / Schleimhautpemphigoid.
Hautarzt
; 69(1): 67-83, 2018 Jan.
Article
en De
| MEDLINE
| ID: mdl-29242962
ABSTRACT
Mucous membrane pemphigoid (MMP) is a pemphigoid disease defined by the presence of autoantibodies against the dermal-epidermal junction and predominant involvement of mucous membranes. Diagnosis is made by the clinical presentation and linear deposits of IgG and/or IgA and/or C3 at the dermal-epidermal junction by direct immunofluorescence microscopy of a perilesional biopsy. Circulating autoantibodies can be detected in most patients by indirect immunofluorescence microscopy on salt-split human skin as well as ELISA and immunoblotting with recombinant and cell-derived target antigens. For systemic treatment of MMP, corticosteroids, dapsone, mycophenolates, and azathioprine are applied. In severe cases and in cases with rapid disease progression cyclophosphamide, rituximab, high-dose intravenous immunoglobulins, and immunoadsorption are used. For the successful management of MMP patients, close cooperation with dentists, ophthalmologists, ENT specialists, gynecologists, and gastroenterologists is essential.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Penfigoide Benigno de la Membrana Mucosa
Límite:
Humans
Idioma:
De
Revista:
Hautarzt
Año:
2018
Tipo del documento:
Article