Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy.
J Am Heart Assoc
; 6(12)2017 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-29246962
ABSTRACT
BACKGROUND:
We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. METHODS ANDRESULTS:
This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (ß=-0.002; P <0.02). The association was strongest in black participants and in men.CONCLUSIONS:
Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
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Isquemia Encefálica
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Función Ventricular Izquierda
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Disfunción Ventricular Izquierda
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Medición de Riesgo
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Vasos Coronarios
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Ventrículos Cardíacos
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Am Heart Assoc
Año:
2017
Tipo del documento:
Article
País de afiliación:
Suecia