Autoimmune hepatitis association with single nucleotide polymorphism of interleukin-2, but not interferon-gamma.
Clin Res Hepatol Gastroenterol
; 42(2): 134-138, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29288086
ABSTRACT
BACKGROUND:
Autoimmune hepatitis (AIH) is a chronic inflammation in hepatocellular tissues associated with circulating autoantibodies. Imbalance in T-cells population and dysregulation in several cytokine profiles has been implicated in pathogenesis of AIH. This study was performed to assess potential association of AIH with interleukin-2 (IL-2) and interferon-gamma (IFN-γ) genes single nucleotide polymorphisms (SNPs).METHODS:
Fifty-six patients with AIH and 139 healthy individuals were enrolled in this study. IL-2 and IFN-γ typing was performed, using polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. The frequencies of alleles, genotypes and haplotypes in AIH patients were compared to healthy controls.RESULTS:
IL-2 T allele at position +166 (rs2069763) showed significant higher frequency in AIH group (36%), compared to the controls (21%) (OR=2.06; 95% CI, 1.24-3.43, P-value<0.01). The frequency of IL-2 TT genotype at +166 position was also associated with AIH (OR=18.68, 95% CI 3.74-126.04, P-value<0.01). G/T alleles of IL-2 at -330 (rs2069762) and A/T alleles on UTR +5644 position at IFN-γ and their subsequent haplotypes, did not show significant association with AIH.CONCLUSIONS:
This study identified IL-2T allele at +166 position and TT genotype as susceptibility gene in AIH which would provide better understandings into the mechanisms of AIH and potential immune modulation therapies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interferón gamma
/
Interleucina-2
/
Hepatitis Autoinmune
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Clin Res Hepatol Gastroenterol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Irán