HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population.
BMC Med Genet
; 19(1): 2, 2018 01 03.
Article
en En
| MEDLINE
| ID: mdl-29298671
ABSTRACT
BACKGROUND:
HLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population.METHODS:
HLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP).RESULTS:
Occurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02 35.09%, C*07 20.19% and C*06 13.6%) were detected. The main HLA class II observed allele groups were DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07 4.45%, A*02-C02 10%, A*23-C*02 8.8%, B*07-C*02 8.8%, B*15-C*02 8.8%) and in class II (DRB1*13-DQB1*06 11.94%, DRB1*03-DQB1*0211.19% and DRB1*03-DQB1*03 10.45%), the majority of locus combination were in the range of 2-3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found.CONCLUSIONS:
These results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-A
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Antígenos HLA-B
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Antígenos HLA-C
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Antígenos HLA-D
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Polimorfismo de Nucleótido Simple
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Población Negra
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Genética de Población
Límite:
Female
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Humans
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Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
BMC Med Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Mauritania