Progesterone-Mediated Inhibition of the GnRH Pulse Generator: Differential Sensitivity as a Function of Sleep Status.
J Clin Endocrinol Metab
; 103(3): 1112-1121, 2018 03 01.
Article
en En
| MEDLINE
| ID: mdl-29300925
ABSTRACT
Context During normal, early puberty, luteinizing hormone (LH) pulse frequency is low while awake but increases during sleep. Mechanisms underlying such changes are unclear, but a small study in early pubertal girls suggested that differential wake-sleep sensitivity to progesterone negative feedback plays a role. Objective:
To test the hypothesis that progesterone acutely reduces waking LH pulse frequency more than sleep-associated pulse frequency in late pubertal girls.Design:
Randomized, placebo-controlled, double-blinded crossover study.Setting:
Academic clinical research unit.Participants:
Eleven normal, postmenarcheal girls, ages 12 to 15 years. Intervention Subjects completed two 18-hour admissions in separate menstrual cycles (cycle days 6 to 11). Frequent blood sampling for LH assessment was performed at 1800 to 1200 hours; sleep was encouraged at 2300 to 0700 hours. Either oral micronized progesterone (0.8 mg/kg/dose) or placebo was given at 0700, 1500, 2300, and 0700 hours, before and during the first admission. A second admission, performed at least 2 months later, was identical to the first except that placebo was exchanged for progesterone or vice versa (treatment crossover). Main OutcomeMeasures:
LH pulse frequency during waking and sleeping hours.Results:
Progesterone reduced waking LH pulse frequency by 26% (P = 0.019), with no change observed during sleep (P = 0.314). The interaction between treatment condition (progesterone vs placebo) and sleep status (wake vs sleep) was highly significant (P = 0.007).Conclusions:
In late pubertal girls, progesterone acutely reduced waking LH pulse frequency more than sleep-associated pulse frequency. Differential wake-sleep sensitivity to progesterone negative feedback may direct sleep-wake LH pulse frequency changes across puberty.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Progestinas
/
Progesterona
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Sueño
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Menarquia
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Hormona Luteinizante
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
Límite:
Adolescent
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Child
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Female
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Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2018
Tipo del documento:
Article