Acute hepatitis as a prequel to very severe aplastic anemia.
Z Gastroenterol
; 56(1): 51-54, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29316578
ABSTRACT
Severe aplastic anemia is a rare and potentially life-threatening disease of the bone marrow often requiring allogeneic hematopoietic stem cell transplantation. Pathogenesis of the disease can vary and often remains enigmatic. Occasionally, severe aplastic anemia is associated with prior severe acute hepatitis. Differential diagnosis of acute non-viral hepatitis challenges the physician as pathogenesis remains unclear.We here present a case of a young patient presenting with acute hepatitis followed by severe aplastic anemia successfully treated with allogeneic hematopoietic stem cell transplantation. Due to immunosuppressive treatment with azathioprine for acute hepatitis of putative autoimmune pathogenesis and coincident infection with parvovirus B19, diagnosis of the sequential disease of acute hepatitis followed by severe aplastic anemia was complicated. We discuss the caveats and present a review of the literature.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Parvovirus B19 Humano
/
Infecciones por Parvoviridae
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Trasplante de Células Madre Hematopoyéticas
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Hepatitis Viral Humana
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Inmunosupresores
/
Anemia Aplásica
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Z Gastroenterol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania