Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action.

Havránková, Eva; Csöllei, Jozef; Vullo, Daniela; Garaj, Vladimír; Pazdera, Pavel; Supuran, Claudiu T

Havránková, Eva; Csöllei, Jozef; Vullo, Daniela; Garaj, Vladimír; Pazdera, Pavel; Supuran, Claudiu T.

Afiliación

Havránková E; University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, Department of Chemical Drugs, Palackého 1-3, CZ-612 42 Brno, Czech Republic; Masaryk University, Faculty of Science, Department of Chemistry, Centre for Syntheses at Sustainable Conditions and Their Management, University Cam
Csöllei J; University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, Department of Chemical Drugs, Palackého 1-3, CZ-612 42 Brno, Czech Republic.
Vullo D; University of Florence, Polo Scientifico, Neurofarba Department, Via Ugo Shiff 6, 500 19 Sesto Fiorentino (Florence), Italy.
Garaj V; Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Odbojárov 10, 832 32 Bratislava, Slovakia.
Pazdera P; Masaryk University, Faculty of Science, Department of Chemistry, Centre for Syntheses at Sustainable Conditions and Their Management, University Campus, Kamenice 753/5, CZ-625 00 Brno, Czech Republic.
Supuran CT; University of Florence, Polo Scientifico, Neurofarba Department, Via Ugo Shiff 6, 500 19 Sesto Fiorentino (Florence), Italy. Electronic address: claudiu.supuran@unifi.it.

Bioorg Chem ; 77: 25-37, 2018 04.

Article en En | MEDLINE | ID: mdl-29324250

Asunto(s)

Amino Alcoholes/farmacología; Inhibidores de Anhidrasa Carbónica/farmacología; Piperazina/farmacología; Sulfonamidas/farmacología; Triazinas/farmacología; Amino Alcoholes/química; Antígenos de Neoplasias/metabolismo; Anhidrasa Carbónica I/antagonistas & inhibidores; Anhidrasa Carbónica I/metabolismo; Anhidrasa Carbónica II/antagonistas & inhibidores; Anhidrasa Carbónica II/metabolismo; Anhidrasa Carbónica IX/antagonistas & inhibidores; Anhidrasa Carbónica IX/metabolismo; Inhibidores de Anhidrasa Carbónica/síntesis química; Inhibidores de Anhidrasa Carbónica/química; Relación Dosis-Respuesta a Droga; Humanos; Estructura Molecular; Piperazina/química; Relación Estructura-Actividad; Sulfonamidas/química; Triazinas/química

Palabras clave

1,3,5-Triazine; Benzene sulfonamides; Carbonic anhydrase; Enzyme inhibition; Isoform selectivity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Triazinas / Inhibidores de Anhidrasa Carbónica / Piperazina / Amino Alcoholes Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2018 Tipo del documento: Article

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