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RBP4: A Culprit for Insulin Resistance in End Stage Renal Disease That Can Be Cleared by Hemodiafiltration.
Grosjean, Fabrizio; Esposito, Pasquale; Maccarrone, Rosario; Libetta, Carmelo; Dal Canton, Antonio; Rampino, Teresa.
Afiliación
  • Grosjean F; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Esposito P; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Maccarrone R; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Libetta C; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Dal Canton A; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
  • Rampino T; Nephrology, Dialysis, Transplant, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Biomed Res Int ; 2017: 7270595, 2017.
Article en En | MEDLINE | ID: mdl-29333450
ABSTRACT

INTRODUCTION:

Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR). In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD). We also assessed how circulating RBP4 could be influenced by kidney transplant or different dialytic techniques.

METHODS:

RBP4 serum levels were evaluated in HD (n = 16) and matched healthy controls (C; n = 16). RBP4 and glucose transporter type 4 (GLUT4) mRNA expressions were also determined in adipose tissue. Circulating RBP4 was evaluated after kidney transplant (n = 7) and in hemodialysis patients (n = 10) enrolled in a cross-over study treated with standard bicarbonate dialysis (BD) or hemodiafiltration (HDF).

RESULTS:

HOMA index (P < 0.05) and serum RBP4 (P < 0.005) were higher in HD compared to C. RBP4 levels positively correlated with fasting serum glucose (P < 0.05). RBP4 mRNA was lower in HD compared to C (P < 0.05) and positively correlated with kidney function (P < 0.05) and GLUT4 mRNA (P < 0.001). Transplant or HDF reduced circulating RBP4 (P < 0.01 and P < 0.05, resp.). Our results demonstrate that IR is associated with high circulating RBP4 and that suppressed RBP4 adipose tissue expression is accompanied by reduced GLUT4 expression in HD. Renal transplantation or HDF are effective in lowering serum RBP4 levels.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Transportador de Glucosa de Tipo 4 / Proteínas Plasmáticas de Unión al Retinol / Fallo Renal Crónico Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2017 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Transportador de Glucosa de Tipo 4 / Proteínas Plasmáticas de Unión al Retinol / Fallo Renal Crónico Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2017 Tipo del documento: Article País de afiliación: Italia