MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47.
Mol Cancer
; 17(1): 12, 2018 01 24.
Article
en En
| MEDLINE
| ID: mdl-29368647
ABSTRACT
Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expression in the immune system. Here, we demonstrate that miR-708 regulates CD47, a transmembrane protein that inhibits phagocytosis in T cell acute lymphoblastic leukemia. miR-708 directly targeted CD47 through binding to 3'UTR and is inversely correlated with CD47 expression. Functional studies showed that restoration of miR-708 expression in the T-ALL cell line is sufficient to promote phagocytosis by macrophages in the absence or presence of the anti-CD47 antibody to eradicate T-ALL cells, and inhibited tumor engraftment in vivo. Together, our findings suggest that miR-708 is a key negative regulator of CD47 and may serve as an attractive candidate for immunotherapy of T-ALL.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fagocitosis
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Regulación Leucémica de la Expresión Génica
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MicroARNs
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Interferencia de ARN
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Antígeno CD47
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
Límite:
Humans
Idioma:
En
Revista:
Mol Cancer
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
China