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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Zhang, Donglu; Le, Hoa; Cruz-Chuh, Josefa Dela; Bobba, Sudheer; Guo, Jun; Staben, Leanna; Zhang, Chenghong; Ma, Yong; Kozak, Katherine R; Lewis Phillips, Gail D; Vollmar, Breanna S; Sadowsky, Jack D; Vandlen, Richard; Wei, BinQing; Su, Dian; Fan, Peter; Dragovich, Peter S; Khojasteh, S Cyrus; Hop, Cornelis E C A; Pillow, Thomas H.
Afiliación
  • Zhang D; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Le H; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Cruz-Chuh JD; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Bobba S; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Guo J; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Staben L; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Zhang C; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Ma Y; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Kozak KR; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Lewis Phillips GD; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Vollmar BS; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Sadowsky JD; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Vandlen R; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Wei B; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Su D; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Fan P; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Dragovich PS; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Khojasteh SC; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Hop CECA; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
  • Pillow TH; Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.
Bioconjug Chem ; 29(2): 267-274, 2018 02 21.
Article en En | MEDLINE | ID: mdl-29369629
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Supervivencia Celular / Inmunoconjugados / Fenol Límite: Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Supervivencia Celular / Inmunoconjugados / Fenol Límite: Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos