Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential.

De Bellis, Michela; Sanarica, Francesca; Carocci, Alessia; Lentini, Giovanni; Pierno, Sabata; Rolland, Jean-François; Conte Camerino, Diana; De Luca, Annamaria

De Bellis, Michela; Sanarica, Francesca; Carocci, Alessia; Lentini, Giovanni; Pierno, Sabata; Rolland, Jean-François; Conte Camerino, Diana; De Luca, Annamaria.

Afiliación

De Bellis M; Unit of Pharmacology, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
Sanarica F; Unit of Pharmacology, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
Carocci A; Unit of Medicinal Chemistry, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
Lentini G; Unit of Medicinal Chemistry, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
Pierno S; Unit of Pharmacology, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
Rolland JF; AXXAM S.p.A., Milan, Italy.
Conte Camerino D; Unit of Pharmacology, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.
De Luca A; Unit of Pharmacology, Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy.

Front Pharmacol ; 8: 907, 2017.

Article en En | MEDLINE | ID: mdl-29379434

Palabras clave

C2C12 cells; anti-myotonic agent; antioxidant action; mexiletine; muscular dystrophy; skeletal muscle; sodium channel; voltage-clamp recordings

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Italia

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Italia