Mitochondrial DNA structure of an isolated Tunisian Berber population and its relationship with Mediterranean populations.
Ann Hum Biol
; 45(1): 86-97, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29382283
ABSTRACT
BACKGROUND:
Douiret is an isolated Berber population from South-Eastern Tunisia. The strong geographic and cultural isolation characterising this population might have contributed to remarkable endogamy and consanguinity, which were practiced for several centuries.AIM:
The objective of this study is to evaluate the mitochondrial DNA (mtDNA) genetic structure of Douiret and to compare it to other Mediterranean populations with a special focus on major haplogroup T. SUBJECTS ANDMETHODS:
Genomic DNA was extracted from blood samples of 58 unrelated individuals collected from the different patrilineal lineages of the population. The hypervariable region 1 of the mtDNA was amplified and sequenced. For comparative analyses, additional HVS1 sequences (n = 4857) were compiled from previous studies.RESULTS:
The maternal background of the studied sample from Douiret was mainly of Eurasian origin (74%) followed by Sub-Saharan (17%) and North African (3%) lineages. Douiret harbours the highest frequency of haplogroup T in the Mediterranean region, assigned to the unique subclade T1a (38%). Phylogenetic analysis showed an outlier position of Douiret at the Mediterranean level.CONCLUSIONS:
The genetic structure of Douiret highlights the presence of founders, most likely of Near/Middle Eastern origin, who conquered this area during the Middle/Late Upper Palaeolithic and Neolithic dispersals.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Haplotipos
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ADN Mitocondrial
/
Etnicidad
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ann Hum Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Túnez