Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb·&#945;-adaptin complex.

Chen, Xing; Liu, Ziheng; Shan, Zelin; Yao, Weiyi; Gu, Aihong; Wen, Wenyu

Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb·α-adaptin complex.

Chen, Xing; Liu, Ziheng; Shan, Zelin; Yao, Weiyi; Gu, Aihong; Wen, Wenyu.

Afiliación

Chen X; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Liu Z; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Shan Z; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Yao W; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Gu A; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wen W; From the Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, State Key Laboratory of Medical Neurobiology and Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China wywen@fudan.ed

J Biol Chem ; 293(11): 4149-4158, 2018 03 16.

Article en En | MEDLINE | ID: mdl-29382713

Asunto(s)

Proteínas 14-3-3/metabolismo; Subunidades alfa de Complejo de Proteína Adaptadora/metabolismo; Endocitosis/fisiología; Proteínas de la Membrana/química; Proteínas de la Membrana/metabolismo; Proteínas del Tejido Nervioso/química; Proteínas del Tejido Nervioso/metabolismo; Proteínas 14-3-3/química; Subunidades alfa de Complejo de Proteína Adaptadora/química; Animales; Sitios de Unión; Catálisis; Dominio Catalítico; Cristalografía por Rayos X; Ratones; Modelos Moleculares; Fosforilación; Unión Proteica; Conformación Proteica; Relación Estructura-Actividad

Palabras clave

14-3-3 protein; Numb; adaptor protein; dual-site binding mode; dynamic assembly; membrane transport; phosphorylation; protein complex; protein-protein interaction; α-adaptin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Subunidades alfa de Complejo de Proteína Adaptadora / Proteínas 14-3-3 / Endocitosis / Proteínas de la Membrana / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article País de afiliación: China

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