Intravoxel incoherent motion magnetic resonance imaging for differentiating metastatic and non-metastatic lymph nodes in pancreatic ductal adenocarcinoma.
Eur Radiol
; 28(7): 2781-2789, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29404768
ABSTRACT
OBJECTIVES:
To evaluate the diagnostic potential of intravoxel incoherent motion (IVIM) DWI for differentiating metastatic and non-metastatic lymph node stations (LNS) in pancreatic ductal adenocarcinoma (PDAC).METHODS:
59 LNS histologically diagnosed following surgical resection from 15 patients were included. IVIM DWI with 12 b values was added to the standard MRI protocol. Evaluation of parameters was performed pre-operatively and included the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f). Diagnostic performance of ADC, D, D* and f for differentiating between metastatic and non-metastatic LNS was evaluated using ROC analysis.RESULTS:
Metastatic LNS had significantly lower D, D*, f and ADC values than the non-metastatic LNS (p< 0.01). The best diagnostic performance was found in D, with an area under the ROC curve of 0.979, while the area under the ROC curve values of D*, f and ADC were 0.867, 0.855 and 0.940, respectively. The optimal cut-off values for distinguishing metastatic and non-metastatic lymph nodes were D = 1.180 × 10-3 mm2/s; D* = 14.750 × 10-3 mm2/s, f = 20.65 %, and ADC = 1.390 × 10-3 mm2/s.CONCLUSION:
IVIM DWI is useful for differentiating between metastatic and non-metastatic LNS in PDAC. KEY POINTS ⢠IVIM DWI is feasible for diagnosing LN metastasis in PDAC. ⢠Metastatic LNS has lower D, D*, f, ADC values than non-metastatic LNS. ⢠D-value from IVIM model has best diagnostic performance, followed by ADC value. ⢠D* has the lowest AUC value.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
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Carcinoma Ductal Pancreático
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Ganglios Linfáticos
Tipo de estudio:
Evaluation_studies
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Guideline
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Observational_studies
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Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Asunto de la revista:
RADIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China