Changes in the Anti-Allergic Activities of Sesame by Bioconversion.
Nutrients
; 10(2)2018 Feb 14.
Article
en En
| MEDLINE
| ID: mdl-29443928
ABSTRACT
Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1ß (IL-1ß), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-κB and STAT1 activation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Semillas
/
Proteínas de Vegetales Comestibles
/
Alérgenos
/
Queratinocitos
/
Citocinas
/
Sesamum
/
Alimentos Fermentados
Tipo de estudio:
Etiology_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nutrients
Año:
2018
Tipo del documento:
Article