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Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report.
Qiao, Yu; Yang, Jihong; Liu, Lili; Zeng, Yixin; Ma, Jie; Jia, Jing; Zhang, Li; Li, Xiaoguang; Wu, Peihong; Wang, Wenchao; Liu, Dongge; Chen, Huan; Zhao, Yunbo; Xi, Huan; Wang, Yao.
Afiliación
  • Qiao Y; Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Yang J; Department of Oncology, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Liu L; Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China. yangjihong3078@bjhmoh.cn.
  • Zeng Y; Department of Nephrology, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China. yangjihong3078@bjhmoh.cn.
  • Ma J; Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Jia J; Department of Nephrology, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Zhang L; Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Li X; Department of Oncology, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Wu P; Biological Treatment Center, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Wang W; Department of Geriatric, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Liu D; Departmnet of Oncology, Tumor Hospital, Zhongshan University, Guangzhou, 510089, People's Republic of China.
  • Chen H; Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Zhao Y; The Center of Medical Image Guided Minimally Invasive Therapy, Tumor Hospital, Zhongshan University, Guangzhou, 510089, People's Republic of China.
  • Xi H; Department of Imaging, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
  • Wang Y; Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing, 100730, People's Republic of China.
BMC Cancer ; 18(1): 212, 2018 02 21.
Article en En | MEDLINE | ID: mdl-29466964
ABSTRACT

BACKGROUND:

Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence and distant metastasis, and poor prognosis. There are no established treatment guidelines for PHA. CASE PRESENTATION A 78-year-old asymptomatic man with PHA that was successfully treated with pazopanib plus PD-1 inhibitor and RetroNectin-activated killer cells (RAK cells). After one month of treatment, there was a clear reduction in the size and number of the liver metastases; and after nearly 15 months, most of the lesions were stable, no new lesions had developed, and the side effect of treatment was minor.

CONCLUSION:

Pazopanib, PD-1 inhibitor and RAK cells could serve as a potential option for the treatment of advanced PHA.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Inmunoterapia Adoptiva / Hemangiosarcoma / Neoplasias Hepáticas Tipo de estudio: Guideline / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Inmunoterapia Adoptiva / Hemangiosarcoma / Neoplasias Hepáticas Tipo de estudio: Guideline / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article