An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.

Cooper, Matthew L; Choi, Jaebok; Staser, Karl; Ritchey, Julie K; Devenport, Jessica M; Eckardt, Kayla; Rettig, Michael P; Wang, Bing; Eissenberg, Linda G; Ghobadi, Armin; Gehrs, Leah N; Prior, Julie L; Achilefu, Samuel; Miller, Christopher A; Fronick, Catrina C; O'Neal, Julie; Gao, Feng; Weinstock, David M; Gutierrez, Alejandro; Fulton, Robert S; DiPersio, John F

Cooper, Matthew L; Choi, Jaebok; Staser, Karl; Ritchey, Julie K; Devenport, Jessica M; Eckardt, Kayla; Rettig, Michael P; Wang, Bing; Eissenberg, Linda G; Ghobadi, Armin; Gehrs, Leah N; Prior, Julie L; Achilefu, Samuel; Miller, Christopher A; Fronick, Catrina C; O'Neal, Julie; Gao, Feng; Weinstock, David M; Gutierrez, Alejandro; Fulton, Robert S; DiPersio, John F.

Afiliación

Cooper ML; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA. matthewcooper@wustl.edu.
Choi J; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Staser K; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ritchey JK; Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Devenport JM; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Eckardt K; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Rettig MP; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Wang B; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Eissenberg LG; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ghobadi A; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gehrs LN; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Prior JL; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Achilefu S; Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA.
Miller CA; Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA.
Fronick CC; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
O'Neal J; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA.
Gao F; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA.
Weinstock DM; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Gutierrez A; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Fulton RS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
DiPersio JF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

Leukemia ; 32(9): 1970-1983, 2018 09.

Article en En | MEDLINE | ID: mdl-29483708

Asunto(s)

Inmunoterapia Adoptiva; Leucemia de Células T/inmunología; Leucemia de Células T/metabolismo; Receptores de Antígenos de Linfocitos T/metabolismo; Receptores Quiméricos de Antígenos/metabolismo; Linfocitos T/inmunología; Animales; Antígenos CD7/genética; Antígenos CD7/inmunología; Antígenos de Neoplasias/genética; Antígenos de Neoplasias/inmunología; Sistemas CRISPR-Cas; Citotoxicidad Inmunológica; Modelos Animales de Enfermedad; Femenino; Eliminación de Gen; Edición Génica; Orden Génico; Vectores Genéticos/genética; Humanos; Inmunoterapia Adoptiva/métodos; Leucemia de Células T/genética; Leucemia de Células T/terapia; Masculino; Ratones; Receptores de Antígenos de Linfocitos T/genética; Receptores Quiméricos de Antígenos/genética; Anticuerpos de Cadena Única/genética; Anticuerpos de Cadena Única/inmunología; Anticuerpos de Cadena Única/metabolismo; Linfocitos T/efectos de los fármacos; Linfocitos T/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Linfocitos T / Leucemia de Células T / Inmunoterapia Adoptiva / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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