Excitatory repetitive transcranial magnetic stimulation applied to the right inferior frontal gyrus has no effect on motor or cognitive impulsivity in healthy adults.
Behav Brain Res
; 347: 1-7, 2018 07 16.
Article
en En
| MEDLINE
| ID: mdl-29505803
ABSTRACT
BACKGROUND:
Impulsivity is a multi-faceted concept. It is a crucial feature of many neuropsychiatric disorders. Three subtypes of impulsivity have been identified motor, temporal, and cognitive impulsivity. Existing evidence suggests that the right inferior frontal gyrus (rIFG) plays a crucial role in impulsivity, and such a role has been elucidated using inhibitory repetitive transcranial magnetic stimulation (rTMS). There is a dearth of studies using excitatory rTMS at the rIFG, an important gap in the literature this study aimed to address.METHODS:
Twenty healthy male adults completed a single-blind sham-controlled randomised crossover study aimed at assessing the efficacy of rTMS in the neuromodulation of impulsivity. This involved delivering 10-Hz excitatory rTMS to the rIFG at the intensity of 100% motor threshold with 900 pulses per session. Trait impulsivity was measured at baseline using the Barrett Impulsiveness Scale and UPPS-P Impulsiveness Scale. The Stop Signal Task (SST) and Information Sampling Task (IST), administered before and after rTMS sessions, were used as behavioural measures of impulsivity.RESULTS:
No significant changes on any measures from either SST or IST after active rTMS at the rIFG compared to the sham-controlled condition were found.CONCLUSIONS:
Excitatory rTMS applied to the rIFG did not have a statistically significant effect on response inhibition and reflective/cognitive impulsivity. Further research is required before drawing firm conclusions. This may involve a larger sample of highly impulsive individuals, a different stimulation site or a different TMS modality such as theta burst stimulation.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Cognición
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Estimulación Magnética Transcraneal
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Lóbulo Frontal
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Conducta Impulsiva
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Actividad Motora
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Humans
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Male
Idioma:
En
Revista:
Behav Brain Res
Año:
2018
Tipo del documento:
Article