Association of CYP2B6 Single-Nucleotide Polymorphisms Altering Efavirenz Metabolism With Hepatitis C Virus (HCV) Treatment Relapse Among Human Immunodeficiency Virus/HCV-Coinfected African Americans Receiving Ledipasvir/Sofosbuvir in the ION-4 Trial.

Kleinstein, Sarah E; Shea, Patrick R; Stamm, Luisa M; Sulkowski, Mark; Goldstein, David B; Naggie, Susanna

Kleinstein, Sarah E; Shea, Patrick R; Stamm, Luisa M; Sulkowski, Mark; Goldstein, David B; Naggie, Susanna.

Afiliación

Kleinstein SE; Institute for Genomic Medicine, Columbia University, New York, New York.
Shea PR; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina.
Stamm LM; Institute for Genomic Medicine, Columbia University, New York, New York.
Sulkowski M; Gilead Sciences, Inc., Foster City, California.
Goldstein DB; Divisions of Infectious Diseases and Hepatology/Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryl.
Naggie S; Institute for Genomic Medicine, Columbia University, New York, New York.

Clin Infect Dis ; 66(12): 1953-1956, 2018 06 01.

Article en En | MEDLINE | ID: mdl-29522085

RESUMEN

In the ION-4 trial, hepatitis C virus relapse was rare, occurring only in African American patients, 80% receiving efavirenz for human immunodeficiency virus infection. We observed no indication that CYP2B6 polymorphisms associated with increased plasma efavirenz exposure explained the relapses.

Asunto(s)

Antivirales/uso terapéutico; Bencimidazoles/uso terapéutico; Benzoxazinas/metabolismo; Citocromo P-450 CYP2B6/genética; Fluorenos/uso terapéutico; Hepatitis C/tratamiento farmacológico; Sofosbuvir/uso terapéutico; Negro o Afroamericano; Alquinos; Benzoxazinas/sangre; Estudios de Cohortes; Coinfección/tratamiento farmacológico; Coinfección/etnología; Coinfección/virología; Ciclopropanos; Quimioterapia Combinada; Femenino; Estudio de Asociación del Genoma Completo; Genotipo; Infecciones por VIH/tratamiento farmacológico; Infecciones por VIH/etnología; Hepacivirus/efectos de los fármacos; Hepatitis C/etnología; Hepatitis C/genética; Humanos; Masculino; Polimorfismo de Nucleótido Simple; Recurrencia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Bencimidazoles / Hepatitis C / Benzoxazinas / Citocromo P-450 CYP2B6 / Fluorenos / Sofosbuvir Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article

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