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An in silico-designed flavone derivative, 6-fluoro-4'-hydroxy-3',5'-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells.
Fujimoto, Kazuhiro J; Nema, Daiki; Ninomiya, Masayuki; Koketsu, Mamoru; Sadanari, Hidetaka; Takemoto, Masaya; Daikoku, Tohru; Murayama, Tsugiya.
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  • Fujimoto KJ; Center for Basic Education, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan.
  • Nema D; Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan.
  • Ninomiya M; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
  • Koketsu M; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
  • Sadanari H; Center for Basic Education, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan.
  • Takemoto M; Center for Basic Education, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan.
  • Daikoku T; Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan.
  • Murayama T; Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan. Electronic address: t-murayama@hokuriku-u.ac.jp.
Antiviral Res ; 154: 10-16, 2018 06.
Article en En | MEDLINE | ID: mdl-29559264
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Ganciclovir / Citomegalovirus / Flavonas / Fibroblastos Límite: Humans Idioma: En Revista: Antiviral Res Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Ganciclovir / Citomegalovirus / Flavonas / Fibroblastos Límite: Humans Idioma: En Revista: Antiviral Res Año: 2018 Tipo del documento: Article País de afiliación: Japón