Dynamic contrast-enhanced MRI of orbital and anterior visual pathway lesions.
Magn Reson Imaging
; 51: 44-50, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29709464
ABSTRACT
PURPOSE:
The accurate diagnosis of orbital and anterior visual pathway lesions has clinical significance. We determined whether dynamic contrast-enhanced MRI could differentiate benign from malignant lesions and compared model-independent and model-dependent methods of data analysis.METHODS:
We retrospectively reviewed dynamic contrast-enhanced MRI studies of 37 enhancing orbital and anterior visual pathway lesions. The data were processed using model-independent analysis and model-dependent analysis using a 2-compartment pharmacokinetic model. The time-signal intensity curve and semiquantitative parameters from the model-independent method (area under the curve [AUC] after the initial 60, 90, and 120â¯s; time to peak; maximum signal enhancement ratio; maximum slope of increase; and washout ratio) and the quantitative parameters from the model-dependent method (Ktrans, kep, and ve) were derived for comparison with pathologic diagnoses.RESULTS:
The time-signal intensity curves demonstrated different perfusion characteristics and were classified into 4 types. All the lesions that demonstrated curve types 1 and 4 were benign, while type 3 lesions were significantly associated with malignancy (Pâ¯=â¯0.001). AUC60, AUC90, AUC120, and kep were significantly lower in benign lesions than in malignant lesions (Pâ¯=â¯0.020, 0.018, 0.015, and 0.018, respectively). Receiver operating characteristic analysis indicated that AUC120 yielded the best diagnostic accuracy (area under the curve, 0.80; 95% CI, 0.64-0.96) in differentiating between benign and malignant lesions.CONCLUSIONS:
Dynamic contrast-enhanced MRI is useful in evaluating orbital and anterior visual pathway lesions. The model-independent analysis method is equivalent to the model-dependent method in differentiating benign from malignant lesions.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Órbita
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Vías Visuales
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Imagen por Resonancia Magnética
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Aumento de la Imagen
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Medios de Contraste
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2018
Tipo del documento:
Article
País de afiliación:
Tailandia