Bicarbonate refractory QRS prolongation and left bundle-branch block following escitalopram and lamotrigine overdose: A case report and literature review of toxic left bundle-branch block.
J Clin Pharm Ther
; 43(5): 717-722, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-29722042
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Toxic prolongation of the QRS interval most often results from blockade of cardiac voltage-gated sodium channels and manifests on electrocardiogram with a right bundle-branch block-like morphology. Rarely, a left bundle-branch block (LBBB) morphology has been reported. CASE REPORT We report a case of transient LBBB resultant from ingestion of lamotrigine and citalopram which was refractory to sodium bicarbonate therapy and eventually resolved spontaneously. WHAT IS NEW ANDCONCLUSION:
Cases of toxic LBBB are less likely to respond to bicarbonate therapy, suggesting that this finding is due to a mechanism other than sodium channel blockade.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
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Bicarbonatos
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Bloqueo de Rama
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Citalopram
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Electrocardiografía
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Lamotrigina
Límite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos