Molecular Characterization of Invasive Isolates of Neisseria meningitidis in Casablanca, Morocco.
J Clin Microbiol
; 56(7)2018 07.
Article
en En
| MEDLINE
| ID: mdl-29743304
ABSTRACT
Meningococcal epidemiology may change unpredictably, and typing of Neisseria meningitidis isolates is crucial for the surveillance of invasive meningococcal disease (IMD). Few data are available regarding the meningococcal epidemiology in countries of North Africa. We aimed to explore invasive meningococcal isolates from the Casablanca region in Morocco. We used whole-genome sequencing (WGS) to characterize 105 isolates from this region during the period of 2011 to 2016. Our data showed that the majority (n = 100) of the isolates belonged to serogroup B. Genotyping indicated that most of the isolates (n = 62) belonged to sequence type 33 of clonal complex 32. The isolates also showed the same PorA and FetA markers and clustered together on the basis of WGS phylogenetic analysis; they seemed to correspond to an expansion of local isolates in the Casablanca region, as reported for similar isolates in several other countries. These data suggest that serogroup B isolates may predominate in Morocco, which may have an important impact in the design of vaccination strategies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Filogenia
/
Infecciones Meningocócicas
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Neisseria meningitidis
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
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Newborn
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Clin Microbiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia