Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.
Atherosclerosis
; 274: 67-76, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29753230
ABSTRACT
BACKGROUND AND AIMS:
Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress.METHODS:
Male Wistar rats were treated with ethanol 20% (vol./vol.) or nebivolol (10â¯mg/kg/day, p. o., gavage), a selective ß1-adrenergic receptor antagonist.RESULTS:
Ethanol-induced increase in blood pressure and in the circulating levels of adrenaline and noradrenaline was prevented by nebivolol. Similarly, nebivolol prevented ethanol-induced increase in plasma levels of renin, angiotensin I and II. Chronic ethanol consumption increased the aortic levels of superoxide anion (O2-), thiobarbituric acid reactive species (TBARS) as well as the expression of Nox1 and nitrotyrosine immunostaining in the rat aorta. Treatment with nebivolol prevented these responses. The decrease in aortic levels of nitrate/nitrite (NOx) induced by ethanol was prevented by the treatment with nebivolol. Finally, nebivolol attenuated ethanol-induced increase in phenylephrine- and noradrenaline-induced contraction of endothelium-intact and endothelium-denuded aortic rings.CONCLUSIONS:
The novelty of our study is that nebivolol prevented ethanol-induced hypertension and vascular oxidative stress. Additionally, we showed that the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS) are important endogenous mediators of the cardiovascular effects of ethanol.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aorta Torácica
/
Estrés Oxidativo
/
Etanol
/
Antagonistas de Receptores Adrenérgicos beta 1
/
Presión Arterial
/
Nebivolol
/
Hipertensión
/
Antihipertensivos
Límite:
Animals
Idioma:
En
Revista:
Atherosclerosis
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil