Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401.
J Nat Prod
; 81(6): 1405-1410, 2018 06 22.
Article
en En
| MEDLINE
| ID: mdl-29786436
ABSTRACT
Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 µM) and three bacterial species (MIC 1.5 to 13 µg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 µM, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Sesquiterpenos
/
Citotoxinas
/
Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2018
Tipo del documento:
Article
País de afiliación:
China