Moderate tibia axial loading promotes discordant response of bone composition parameters and mechanical properties in a hindlimb unloading rat model.
J Musculoskelet Neuronal Interact
; 18(2): 152-164, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29855437
ABSTRACT
OBJECTIVES:
The purpose of the present study was to characterize the dynamic alterations of bone composition parameters and mechanical properties to disuse and mechanical intervention.METHODS:
A tail suspension hindlimb unloading model and an in vivo axial tibia loading model in rats were used. A moderate mechanical loading that was capable of engendering 800 µÎµ tibia strain was applied to the right tibia of rats in both control and hindlimb unloading group across 28 days of the experimental period. The contralateral tibia served as control.RESULTS:
Hindlimb unloading led to bone loss in tibia from day 14. Bone mineral density, mineral content and mechanical properties responded differently with microstructure to disuse in timing course. Mechanical loading of 800 µÎµ tibia strain failed to alter the bone of the control group, but minimized the detrimental effects of unloading by completely prohibiting the decrease of bone mineral content and main mechanical properties after 28 days. Less obvious influence of mechanical loading on bone microstructure was found.CONCLUSIONS:
The moderate mechanical loading is not able to stimulate the mechanical response of healthy tibia, but indeed lead to discordant recovery of bone composition parameters and mechanical properties.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tibia
/
Densidad Ósea
/
Soporte de Peso
Límite:
Animals
Idioma:
En
Revista:
J Musculoskelet Neuronal Interact
Asunto de la revista:
FISIOLOGIA
/
NEUROLOGIA
/
ORTOPEDIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China