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A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
Racz, Boglarka; Varadi, Andras; Kong, Jian; Allikmets, Rando; Pearson, Paul G; Johnson, Graham; Cioffi, Christopher L; Petrukhin, Konstantin.
Afiliación
  • Racz B; Department of Ophthalmology, Columbia University, New York, New York 10032.
  • Varadi A; Department of Ophthalmology, Columbia University, New York, New York 10032.
  • Kong J; Department of Ophthalmology, Columbia University, New York, New York 10032.
  • Allikmets R; Department of Ophthalmology, Columbia University, New York, New York 10032; Department of Pathology and Cell Biology, Columbia University, New York, New York 10032.
  • Pearson PG; Pearson Pharma Partners, Westlake Village, California 91361.
  • Johnson G; NuPharmAdvise LLC, Sanbornton, New Hampshire 03269.
  • Cioffi CL; Departments of Basic and Clinical Sciences and Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York 12208.
  • Petrukhin K; Department of Ophthalmology, Columbia University, New York, New York 10032. Electronic address: kep4@cumc.columbia.edu.
J Biol Chem ; 293(29): 11574-11588, 2018 07 20.
Article en En | MEDLINE | ID: mdl-29871924
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Retina / Ácidos Carboxílicos / Proteínas Plasmáticas de Unión al Retinol / Enfermedad de Stargardt Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Retina / Ácidos Carboxílicos / Proteínas Plasmáticas de Unión al Retinol / Enfermedad de Stargardt Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article