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Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo.
Zhang, Qian-Yu; Ho, Pui Yan; Tu, Mei-Juan; Jilek, Joseph L; Chen, Qiu-Xia; Zeng, Su; Yu, Ai-Ming.
Afiliación
  • Zhang QY; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA.
  • Ho PY; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA.
  • Tu MJ; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA.
  • Jilek JL; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA.
  • Chen QX; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  • Zeng S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  • Yu AM; Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA. Electronic address: aimyu@ucdavis.edu.
Int J Pharm ; 547(1-2): 537-544, 2018 Aug 25.
Article en En | MEDLINE | ID: mdl-29894758
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / ARN Interferente Pequeño / Interferencia de ARN / Tratamiento con ARN de Interferencia / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Pharm Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / ARN Interferente Pequeño / Interferencia de ARN / Tratamiento con ARN de Interferencia / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Pharm Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos