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The Role of Xist in X-Chromosome Dosage Compensation.
Sahakyan, Anna; Yang, Yihao; Plath, Kathrin.
Afiliación
  • Sahakyan A; David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Yang Y; David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Plath K; David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.
Trends Cell Biol ; 28(12): 999-1013, 2018 12.
Article en En | MEDLINE | ID: mdl-29910081
ABSTRACT
In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via X-chromosome inactivation (XCI), initiating early in development. Although XCI events are conserved in mouse and human postimplantation development, regulation of X-chromosome dosage in preimplantation development occurs differently. In preimplantation development, mouse embryos undergo imprinted form of XCI, yet humans lack imprinted XCI and instead regulate gene expression of both X chromosomes by dampening transcription. The long non-coding RNA Xist/XIST is expressed in mouse and human preimplantation and postimplantation development to orchestrate XCI, but its role in dampening is unclear. In this review, we discuss recent advances in our understanding of the role of Xist in X chromosome dosage compensation in mouse and human.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromosoma X / Inactivación del Cromosoma X / ARN Largo no Codificante Límite: Animals / Humans Idioma: En Revista: Trends Cell Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromosoma X / Inactivación del Cromosoma X / ARN Largo no Codificante Límite: Animals / Humans Idioma: En Revista: Trends Cell Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos