New concepts in neuroinflammation: mast cells pro-inflammatory and anti-inflammatory cytokine mediators.
J Biol Regul Homeost Agents
; 32(3): 449-454, 2018.
Article
en En
| MEDLINE
| ID: mdl-29921369
ABSTRACT
The activation of brain nociceptors and neurons may lead to neurogenic inflammation, an event that involves immune cells including mast cells (MCs). Microglia are similar to macrophages and secrete pro-inflammatory IL-1 family members and TNF. TNF is rapidly released (first 10 minutes from MC granules) and is subsequently secreted along with other pro-inflammatory cytokines with a new synthesis after several hours. MC-derived TNF is a very powerful pro-inflammatory cytokine which mediates sensitization of the meningeal nociceptors. Here, we report the involvement of MCs in neuroinflammation, the role of inflammatory cytokine IL-1 family members, and of TNF, as well as the potential inhibition of IL-37.
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Banco de datos:
MEDLINE
Asunto principal:
Interleucina-1
/
Mediadores de Inflamación
/
Mastocitos
Límite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia