MANF protects dopamine neurons and locomotion defects from a human &#945;-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.

Zhang, Zhuoyu; Shen, Yijue; Luo, Hang; Zhang, Fen; Peng, Dan; Jing, Li; Wu, Yuanyuan; Xia, Xiaofei; Song, Yunping; Li, Wei; Jin, Lingjing

MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.

Zhang, Zhuoyu; Shen, Yijue; Luo, Hang; Zhang, Fen; Peng, Dan; Jing, Li; Wu, Yuanyuan; Xia, Xiaofei; Song, Yunping; Li, Wei; Jin, Lingjing.

Afiliación

Zhang Z; Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, People's Republic of China.
Shen Y; Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, People's Republic of China.
Luo H; Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, People's Republic of China.
Zhang F; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Peng D; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Jing L; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Wu Y; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Xia X; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Song Y; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China.
Li W; Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, People's Republic of China; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China. Electronic address: liw@tong
Jin L; Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, People's Republic of China. Electronic address: lingjingjin@163.com.

Exp Neurol ; 308: 59-71, 2018 10.

Article en En | MEDLINE | ID: mdl-29959908

Asunto(s)

Neuronas Dopaminérgicas/metabolismo; Neuronas Dopaminérgicas/patología; Estrés del Retículo Endoplásmico/fisiología; Factores de Crecimiento Nervioso/metabolismo; Trastornos Parkinsonianos/fisiopatología; alfa-Sinucleína/metabolismo; Animales; Animales Modificados Genéticamente; Autofagia/fisiología; Caenorhabditis elegans; Modelos Animales de Enfermedad; Humanos; Locomoción/fisiología; Degeneración Nerviosa/metabolismo; Degeneración Nerviosa/patología; Degeneración Nerviosa/fisiopatología; Neuroprotección/fisiología; Trastornos Parkinsonianos/metabolismo; Trastornos Parkinsonianos/patología

Palabras clave

Autophagy; C. elegans; Calcium; ER stress; MANF; Neuroprotection; Parkinson's disease; α-synuclein

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos Parkinsonianos / Alfa-Sinucleína / Neuronas Dopaminérgicas / Estrés del Retículo Endoplásmico / Factores de Crecimiento Nervioso Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Exp Neurol Año: 2018 Tipo del documento: Article

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