Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition.
Carcinogenesis
; 39(11): 1411-1418, 2018 12 13.
Article
en En
| MEDLINE
| ID: mdl-30010814
ABSTRACT
The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Neoplasias de la Mama
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Carcinoma
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Moléculas de Adhesión Celular
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Células Epiteliales
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Antígenos de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Carcinogenesis
Año:
2018
Tipo del documento:
Article
País de afiliación:
República Checa