Good concordance of HPV detection between cervico-vaginal self-samples and general practitioner-collected samples using the Cobas 4800 HPV DNA test.
BMC Infect Dis
; 18(1): 348, 2018 07 27.
Article
en En
| MEDLINE
| ID: mdl-30053836
ABSTRACT
BACKGROUND:
Studies comparing self-samples and clinician-collected samples for high-risk human papillomavirus (HPV) detection using clinically validated PCR-based HPV DNA assays are limited. We measured the concordance of HPV detection between home-based self-sampling and general practitioner (GP) sampling using the Cobas 4800 HPV DNA test and studied women's accept of home-based self-sampling.METHODS:
Paired GP-collected samples and cervico-vaginal self-samples were obtained from 213 women aged 30-59 years diagnosed with ASC-US within the cervical cancer screening program. After undergoing cervical cytology at their GP, the women collected a self-sample with the Evalyn Brush at home and completed a questionnaire. Both samples were HPV-tested using the Cobas 4800 test. Histology results were available for those who tested HPV positive in GP-collected samples.RESULTS:
We observed good concordance for HPV detection between self-samples and GP-collected samples (κ 0.70, 95% CI 0.58-0.81). No underlying CIN2+ cases were missed by self-sampling. Women evaluated that self-sampling was easy (97.2%, 95% CI 93.9-98.9%) and comfortable (94.8%, 95% CI 90.9-97.4%).CONCLUSIONS:
Home-based self-sampling using the Evalyn Brush and the Cobas 4800 test is an applicable and reliable alternative to GP-sampling.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Manejo de Especímenes
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Infecciones por Papillomavirus
/
Pruebas de ADN del Papillomavirus Humano
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
BMC Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Dinamarca