Modulation of cortical circuits by top-down processing and arousal state in health and disease.
Curr Opin Neurobiol
; 52: 172-181, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30064117
ABSTRACT
In this review, we explore how contextual modulations of sensory processing are implemented within the local cortical circuit. We focus on contextual influences of global arousal state (e.g. how alert am I?), sensory predictions (e.g. which stimuli do I expect?), and top-down attention (what is relevant to me?). We review recent literature suggesting that these operations are implemented throughout sensory cortices, and are mediated by excitatory and inhibitory local circuits. By focusing on the circuit mechanisms of contextual modulation operations, we may begin to understand how mutations in GABAergic interneurons and alterations in neuromodulatory signaling lead to specific deficits of information processing in neuropsychiatric disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nivel de Alerta
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Neuronas GABAérgicas
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Corteza Sensoriomotora
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Interneuronas
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Red Nerviosa
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Vías Nerviosas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Opin Neurobiol
Asunto de la revista:
BIOLOGIA
/
NEUROLOGIA
Año:
2018
Tipo del documento:
Article