Maternal plasma metabolic fingerprint indicative for fetal Down syndrome.
Prenat Diagn
; 38(11): 876-882, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30094843
ABSTRACT
OBJECTIVE:
The objective of the study was to perform maternal plasma metabolic fingerprinting to evaluate differences in plasma metabolites between healthy and Down syndrome (DS) pregnancies and to indicate novel non-invasive markers for DS prenatal diagnostics.METHODS:
This was a case-control study of pregnancies between 15th and 18th gestational week. LC-MS-based metabolic fingerprinting of plasma samples was performed.RESULTS:
Levels of five metabolites were significantly lower in the plasma of DS pregnancies. The majority of the statistically significant metabolites may be connected with fetal brain and central nervous system development (eg, fatty acid amides). According to the receiver operating characteristic (ROC), the combination of linoleamide and piperine has the highest diagnostic potential area under the curve (AUC) = 0.878, sensitivity of 100%, and specificity of 73.3%.CONCLUSIONS:
The study indicates disturbances in maternal metabolic pathways evoked by fetal DS. Novel potential maternal plasma metabolomic markers for non-invasive prenatal diagnostics of fetal DS are proposed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasma
/
Síndrome de Down
/
Metaboloma
/
Enfermedades Fetales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Prenat Diagn
Año:
2018
Tipo del documento:
Article
País de afiliación:
Polonia