Residence time distribution of a continuously-operated capsule filling machine: Development of a measurement technique and comparison of three volume-reducing inserts.
Int J Pharm
; 550(1-2): 180-189, 2018 Oct 25.
Article
en En
| MEDLINE
| ID: mdl-30110621
ABSTRACT
This paper presents the measurement and analysis of the residence time distribution (RTD) of a tamping-pin capsule filling machine. The tamping speed and the amount of material inside the powder bowl proved to have a significant effect on the RTD. Various inserts into the powder bowl that reduce the volume and alter mixing and transport in the bowl were experimentally investigated. To obtain the RTD, a tracer-based measurement method was applied and a sophisticated data processing strategy was developed. The tracer-based method also allowed investigations of stagnant zones in the powder bowl, another important aspect in continuous manufacturing (CM). The suitability of tracer material was assessed based on a detailed characterization of bulk and tracer material. Characteristic parameters of the RTD were extracted and compared, proposing a systematic strategy for selection of a suitable insert.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polvos
/
Cápsulas
/
Composición de Medicamentos
Idioma:
En
Revista:
Int J Pharm
Año:
2018
Tipo del documento:
Article
País de afiliación:
Austria