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Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Godinho, Bruno M D C; Henninger, Nils; Bouley, James; Alterman, Julia F; Haraszti, Reka A; Gilbert, James W; Sapp, Ellen; Coles, Andrew H; Biscans, Annabelle; Nikan, Mehran; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia.
Afiliación
  • Godinho BMDC; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: bruno.godinho@umassmed.edu.
  • Henninger N; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Bouley J; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Haraszti RA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Gilbert JW; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Sapp E; Department of Neurology, Mass General Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.
  • Coles AH; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Biscans A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Nikan M; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Echeverria D; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • DiFiglia M; Department of Neurology, Mass General Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.
  • Aronin N; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: anastasia.khvorova@umassmed.edu.
Mol Ther ; 26(11): 2580-2591, 2018 11 07.
Article en En | MEDLINE | ID: mdl-30143435
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / ARN Interferente Pequeño / Proteína Huntingtina / Neuronas Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / ARN Interferente Pequeño / Proteína Huntingtina / Neuronas Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article