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A review of the neurobiological underpinning of comorbid substance use and mood disorders.
Gómez-Coronado, Nieves; Sethi, Rickinder; Bortolasci, Chiara Cristina; Arancini, Lauren; Berk, Michael; Dodd, Seetal.
Afiliación
  • Gómez-Coronado N; Unidad de Gestión Clínica Salud Mental, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Department of Psychiatry, Hospital San Agustín ORL, Dos Hermanas, Sevilla, Spain.
  • Sethi R; London Health Sciences Centre, Western University, London, Canada.
  • Bortolasci CC; Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, VIC, Australia.
  • Arancini L; IMPACT Strategic Research Centre, Deakin University, Geelong, VIC, Australia.
  • Berk M; IMPACT Strategic Research Centre, Deakin University, Geelong, VIC, Australia; University Hospital Geelong, Barwon Health, Geelong VIC, Australia; Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia; Orygen, The National Centre for Excellence in Youth Mental Health, Parkv
  • Dodd S; IMPACT Strategic Research Centre, Deakin University, Geelong, VIC, Australia; University Hospital Geelong, Barwon Health, Geelong VIC, Australia; Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia; Orygen, The National Centre for Excellence in Youth Mental Health, Parkv
J Affect Disord ; 241: 388-401, 2018 12 01.
Article en En | MEDLINE | ID: mdl-30145509
BACKGROUND: There is evidence that substance use disorders and other mental disorders may have shared biological mechanisms. However, the neurobiological basis of this comorbidity remains only partially explained. This review describes the historical evolution of the dual disorders concept and approach, and reviews the existing literature on neurobiological findings specifically regarding comorbid substance use and mood disorders. METHODS: Searches were conducted using PubMed and Scopus in December 2017. A Boolean search was performed using combinations of "dual diagnosis" or "dual disorder" or "depression" or "bipolar" or "affective disorder" or "mood disorder" and "substance use" or "substance abuse" and "neurobiology" or "functional neuroimaging" or "genetics" or "neurotransmitters" or "neuroendocrinology" in the title or abstract, or as keywords, using no language restriction. RESULTS: 32 studies met the inclusion criteria. We found robust evidence for involvement of the neurotransmitters dopamine, GABA and glutamate and their receptors, as well as by the central corticotrophin-releasing hormone, hypothalamic-pituitary-adrenal axis activation, oxidative stress and inflammation. Recent studies focusing on neuroimaging and genetics have not shown consistent results. LIMITATIONS: Only two search tools were used; most identified studies excluded the population of interest (comorbid mood and substance abuse disorders). CONCLUSIONS: The neurobiological relevance for the occurrence of comorbid mood and substance abuse disorders has not been fully elucidated. Considering the high levels of individuals who experience comorbidity in these areas as well as the negative associated outcomes, this is clearly an area that requires further in-depth investigation. Furthermore, findings from this area can help to inform drug abuse prevention and intervention efforts, and especially how they relate to populations with psychiatric symptoms.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos del Humor / Trastornos Relacionados con Sustancias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2018 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos del Humor / Trastornos Relacionados con Sustancias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2018 Tipo del documento: Article País de afiliación: España