The novel diagnostic marker in low-LVEF heart failure patients.
Bratisl Lek Listy
; 119(7): 421-424, 2018.
Article
en En
| MEDLINE
| ID: mdl-30160130
ABSTRACT
OBJECTIVE:
The structural and compositional changes in the myocardium seem to have a major role in the development of heart failure (HF).Imbalance between production and degradation in extracellular collagen results in increase of collagen synthesis biomarkers in the circulation as the carboxy-terminal propeptide of type I procollagen (PIP). Here we aimed to determine role of PIP in the diagnosis of chronic HF. MATERIAL ANDMETHODS:
87 patients with HF group and 80 healthy subjects were enrolled into the study. Echocardiographic examination was performed.At the beginning of the study, serum B type natriuretic peptide (BNP), PIP, high sensitive C-reactive protein (hs-CRP) were measured . The subjects were followed for one year then after.RESULTS:
Average PIP value of HF group was significantly higher than that of the control group (p < 0.001). Both hs-CRP and BNP values were well correlated to PIP values (p < 0.001). In the HF group, PIP value of patients who died at the end of one year was similar to that of patients who survived at the end of first year.CONCLUSION:
PIP may not mirror acute events in follow-up of chronic heart failure but it is a very beneficial biomarker in diagnosis of low-LVEF heart failure with high sensitivity and specificity (Tab. 2, Fig. 1, Ref. 16).Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
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Proteína C-Reactiva
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Biomarcadores
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Procolágeno
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Disfunción Ventricular Izquierda
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Péptido Natriurético Encefálico
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Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Bratisl Lek Listy
Año:
2018
Tipo del documento:
Article